Endocrine Abstracts

Zoledronic acid (5 mg) is used as an annual intravenous infusion for the treatment of post menopausal Osteoporosis, Paget's disease, Hypercalcaemia and more recently complex regional pain syndrome. Zoledronic acid is a potent anti-resorptive preparation used to slow bone breakdown, increase bone density and decrease the amount of Calcium released from the bones into the blood. Previously patients were reviewed in the outpatients clinic whereby bloods tests, Parathyroid hormone...

Introduction: The prevalence of hypertension in children and adolescent who were extremely preterm newborns (EP; ≤32 gestational weeks) has been found to be higher than in those born at term. The causes have not been well characterized. Studies support that adrenal dysregulation might be a consequence of prematurity.Objectives: To determinate if children who were EP had higher adrenal hormones and vascular remodeling biomarker than term newborn (&#...

Introduction: Obesity is a pathological condition characterized by a low-grade systemic inflammatory state that predisposes to the onset of some diseases, such as hypertension, diabetes, and hyperlipidemia. Also, obesity can impact bone metabolism, but its effects are controversial.Aims: This observational study aimed to evaluate and correlate the bone mass with the lipidic profile, adipocytokines, glucose metabolism, hepatic function and purine metaboli...

Background and Objective: Severe metabolic complications generally manifest at an early age in Berardinelli – Seip congenital lipodystrophy (BSCL) and their management is especially challenging, often requiring prompt pharmacological treatment with insulin-sensitizers, lipid lowering drugs, insulin and eventually metreleptin. Nutritional intervention with low lipid personalized diets is considered by experts a fundamental tool in handling the disease when associated with ...

Objectives: Metabolic dysfunction–associated fatty liver disease (MAFLD) is a new nomenclature for fatty liver disease (FLD). The clinical impact of the change in nomenclature on the ability to identify individuals at risk for cardiovascular disease (CVD) has not yet been elucidated. The aim of this study is to describe the cardiovascular risk and subclinical CVD of the different MAFLD subtypes.Methods: Retrospective analysis of patients who attende...

Introduction: Continuous subcutaneous insulin infusion (CSII) therapy in type 1 diabetes (T1D) reduces the risk of hypoglycemia. Hypoglycemia remains a treatment-limiting factor. Impared hypoglycemia awareness (IHA) occurs in 25% of T1D cases and seems to be underestimated by continuous glucose monitoring (CGM). Glycemic variability (GV) is a increasingly valued parameter as a predictor of hypoglycemia and risk of chronic complications.Objective: Analysi...

Background: In type 1 diabetes (T1D), quality of life (QoL) and the effectiveness of treatment influence each other. QoL has been associated with glycaemic control assessed by HbA1c in T1D on continuous subcutaneous insulin infusion (CSII), but data on the relationship between Continuous Glucose Monitoring (CGM) metrics and QoL are scarce.Objectives: To assess QoL and the association between CGM metrics and QoL in T1D on CSII.Metho...

Introduction: Inferior petrosal sinus sampling (IPSS) has been considered to be the gold standard for differential diagnosis of Cushing’s Disease (CD) and ectopic ACTH secretion (EAS).Aim: To describe the experience of our centre in performing IPSS, its safety and efficacy; assess remission rates from transphenoidal surgery and clinical course; approach to the difficulty in the etiological diagnosis of ACTH-dependent Cushing’s Syndrome.<p c...

Introduction: Diabetes is the leading worldwide cause of chronic kidney disease, which is diagnosed by measuring albuminuria and estimating glomerular filtration rate (GFR) with creatinine-based formulas, such as the 2009 CKD-EPI developed in the United States of America (USA). Nonetheless, the race coefficient (RC), present in the 2009 CKD-EPI, may overestimate GFR in other countries.Aim: The goal of this systematic review and meta-analysis was to asses...

Introduction: Thyrotoxic crisis is a rare endocrinological emergency with high mortality and it is more frequent in Graves’ disease.Clinical case: A 66-year-old women with schizophrenia was admitted to the Emergency Department due to altered state of consciousness, fatigue, constant moaning interspersed with unusual psychomotor agitation, heteroaggressiveness, diarrhea and anorexia. Lack of compliance with her psychiatric medication, new delusional ...